Cov hniav lwj tau zoo thawj zaug

2024 Tus sau: Seth Attwood | [email protected]. Kawg hloov kho: 2023-12-16 16:06

Cov kws tshawb fawb Askiv tau pom tias kev sim tshuaj rau Alzheimer's kab mob txhawb kev loj hlob ntawm cov kab noj hniav hauv cov hniav ntawm nas. Nrog nws cov kev pab, koj muaj peev xwm ua tau ib tug tiag tiag kho mob rau caries, nyob rau hauv sib piv rau cov tsos mob nyem uas filling muab. Cov txiaj ntsig kev tshawb fawb tau luam tawm hauv Cov Ntawv Qhia Txog Kev Tshawb Fawb.

Daim duab qhia txog tideglusib molecule

Cov hniav lwj yog kev puas tsuaj ntawm cov tawv nqaij ntawm cov hniav los ntawm cov kua qaub uas tsim los ntawm cov kab mob hauv qhov ncauj. Lub Koom Haum Ntiaj Teb Kev Noj Qab Haus Huv kwv yees tias yuav luag txhua tus neeg laus raug cuam tshuam los ntawm tus kab mob no nyob rau qee lub sijhawm hauv lawv lub neej. Nrog rau qhov nce ntawm cov hniav tsis xws luag, nws tuaj yeem ncav cuag nws cov ntaub so ntswg thiab ua rau lawv o - pulpitis. Pulp qia hlwb tuaj yeem tsim ib txheej me me ntawm dentin (cov khoom tseem ceeb ntawm cov hniav), tab sis lawv tsis tuaj yeem kaw tag nrho cov kab noj hniav, txij li lawv cov kev ua haujlwm raug txwv los ntawm enzyme glycogen synthase kinase 3 (GSK-3). Tib lub enzyme plays lub luag haujlwm tseem ceeb hauv kev txhim kho Alzheimer's kab mob, hom 2 mob ntshav qab zib, o, mob qog noj ntshav, thiab kev puas siab puas ntsws bipolar. Tam sim no, ob peb lub cev tsis muaj zog molecular hnyav ntawm GSK-3 tau raug tsim ua ke, ib qho ntawm lawv, tideglusib, tab tom nrhiav kev sim tshuaj hauv Alzheimer's kab mob.

Muab lub luag haujlwm ntawm cov enzyme no hauv kev txhim kho cov hniav caries, cov kws tshawb fawb ntawm King's College London tau sim peb ntawm nws cov antagonists - BIO, CHIR99021 thiab tideglusib - nyob rau hauv cov nas uas muaj qhov tsis xws luag hauv cov molars loj. Ib biodegradable collagen daim txhuam cev nrog kev npaj tau muab tso rau hauv cov teeb meem no, uas tau nqus tau thaum lub dentin loj tuaj.

Nws muab tawm tias tag nrho cov kev npaj txhawb kev loj hlob ntawm dentin nyob rau hauv carious kab noj hniav. Nyob rau tib lub sijhawm, lub pulp khaws nws txoj kev vam meej thiab tsis muaj cov tsos mob ntawm atrophy, uas tsis tau pom nyob rau hauv cov tsiaj los ntawm pawg tswj hwm. Nyob rau tib lub sijhawm, kev siv tideglusib coj mus rau kev tshem tawm tag nrho cov hniav tsis zoo. Cov tshuaj tsis ua rau muaj kev cuam tshuam. Yog li, GSK-3 antagonists zoo ua rau lub ntuj tsim kho ntawm tus hniav, tshem tawm qhov xav tau kev txhaws, cov kws tshawb fawb xaus lus.

Muab hais tias collagen daim txhuam cev tau pom zoo siv rau hauv cov tshuaj thiab kev nyab xeeb ntawm tideglusib tau raug lees paub hauv kev sim tshuaj thaum ntxov, txoj kev kho tshiab rau caries yuav raug qhia sai sai, raws li tus thawj coj sau Paul Sharpe. Qhov yooj yim ntawm txoj kev no yuav tso cai rau nws siv rau hauv txhua qhov chaw kho hniav.

Qhov no tsis yog thawj zaug uas cov tshuaj tau pom cov lus qhia tshiab rau kev siv. Ntawm cov tshuaj uas twb muaj lawm, ib qho piv txwv zoo yog minoxidil, uas tau tsim los ua tus neeg sawv cev tiv thaiv kab mob siab, tab sis tau dhau los ua ib qho txiaj ntsig zoo ntawm cov plaub hau kev loj hlob. Cov kev sim tsis ntev los no tau pom tias kev sib xyaw ua ke ntawm cov tshuaj tiv thaiv kab mob ntshav qab zib mellitus metformin thiab cov tshuaj tiv thaiv ntshav siab syrosingopine muaj kev tiv thaiv mob qog noj ntshav. Tib yam khoom tau pom nyob rau hauv cov tshuaj tiv thaiv kab mob diclofenac.