Neuroscientist piav qhia vim li cas kev yoo mov thiaj li muaj txiaj ntsig

2024 Tus sau: Seth Attwood | [email protected]. Kawg hloov kho: 2023-12-16 16:06

Hauv qab no yog cov lus hais los ntawm Mark Matson, tus thawj coj tam sim no ntawm National Institute on Aging Laboratory of Neuroscience.

Nws kuj yog tus xibfwb ntawm neuroscience ntawm Johns Hopkins University thiab yog ib tus kws tshawb fawb tseem ceeb hauv cov txheej txheem cellular thiab molecular hauv qab cov kab mob neurodegenerative xws li Parkinson's thiab Alzheimer's.

Kuv tau txiav txim siab los hais txog cov tuam txhab tshuaj vim tias tsab xov xwm no yog hais txog lawv ib yam nkaus. Nyob rau hauv xyoo tas los no, muaj ntau yam piv txwv ntawm cov tuam txhab tshuaj tswj kev tshawb fawb luam tawm.

Qhov no yog vim li cas Harvard University of Medicine xibfwb Arnold Seymour Rahlman tau tshaj tawm rau pej xeem tias txoj haujlwm kho mob tau yuav los ntawm kev lag luam tshuaj.

Qhov no yog vim li cas Dr. Richard Horton, editor-in-chief ntawm The Lancet, tsis ntev los no tau hais tias feem ntau ntawm cov ntaub ntawv tshawb fawb niaj hnub no tsuas yog tsis muaj tseeb.

Qhov no yog vim li cas Dr. Marcia Angell, yav dhau los tus thawj tswj hwm ntawm The New England Journal of Medicine, tau hais tias "kev lag luam kws tshuaj nyiam ua txuj ua kev tshawb fawb thiab kev lag luam thiab tsim cov tshuaj tshiab. Qhov no tsis muaj tseeb kiag li."

Qhov no yog vim li cas John Ioannidis, kws kho mob kis mob ntawm Stanford University Tsev Kawm Ntawv Tshuaj Kho Mob, tau tshaj tawm ib tsab xov xwm hu ua Vim Li Cas Kev Tshawb Fawb Tshaj Lij Tshaj Lij Tshaj Lij Tshaj Lij Tshaj Lij. Tom qab ntawd nws tau dhau los ua cov ntawv tshaj tawm uas tau nyeem ntau tshaj plaws hauv keeb kwm ntawm Public Library of Science."

“Vim li cas peb pluas noj ib hnub ntxiv rau cov khoom noj txom ncauj suav tias yog zaub mov ib txwm muaj? Hauv kuv lub tswv yim, qhov no yog deb ntawm txoj kev noj qab haus huv tshaj plaws rau kev noj haus, thiab muaj ntau yam pov thawj los txhawb kuv lub tswv yim. Peb raug yuam kom noj cov zaub mov no vim tias muaj nyiaj ntau heev. Kev lag luam zaub mov puas yuav tau nyiaj yog tias kuv hla kuv pluas tshais hnub no? Tsis yog, hauv qhov no nws yuav plam lawv. Yog tias tib neeg tshaib plab, kev lag luam zaub mov poob nyiaj. Yuav ua li cas txog kev lag luam kws tshuaj? Yog tias tib neeg tshaib plab qee zaum, tawm dag zog ib ntus thiab noj qab nyob zoo, kev lag luam tshuaj puas yuav ua rau cov neeg noj qab haus huv?"

Mark thiab nws pab neeg tau tshaj tawm ob peb tsab xov xwm qhia tias kev yoo mov ob zaug hauv ib lub lis piam tuaj yeem txo qhov kev pheej hmoo ntawm Parkinson's thiab Alzheimer's.

Nws paub tias kev hloov pauv kev noj haus muaj txiaj ntsig zoo rau lub hlwb. Hauv cov menyuam yaus uas muaj qaug dab peg, kev txwv tsis pub calorie lossis kev yoo mov ua rau txo qis qaug dab peg. Kev yoo mov yog xav tias yuav pab ua kom muaj kev tiv thaiv cov txheej txheem uas tiv thaiv cov teeb meem kev ntxhov siab uas tshwm sim hauv cov neeg mob qaug dab peg (qee tus menyuam muaj mob vwm, txawm li cas los xij, tau txais txiaj ntsig los ntawm kev noj zaub mov tshwj xeeb fatty, low-carb.)

Lub paj hlwb noj qab haus huv, raug "dhau lawm," tej zaum yuav muaj lwm yam kev tswj tsis tau zoo uas cuam tshuam rau kev ua haujlwm ntawm lub hlwb."

Zuag qhia tag nrho, thaum koj saib cov kev tshawb fawb txog qhov cuam tshuam ntawm kev txwv calorie, ntau ntawm lawv qhia tias kev noj haus ua rau lub neej ntev thiab txhim kho lub peev xwm tiv thaiv kab mob ntev.

Kev yoo mov yog qhov zoo rau lub hlwb, thiab qhov no tuaj yeem pom hauv cov kev hloov pauv neurochemical uas tshwm sim hauv lub hlwb thaum peb tshaib plab.

Nws kuj tseem txhim kho kev paub txog kev ua haujlwm, ua kom muaj cov kab mob neurotrophic, ua rau kom muaj kev ntxhov siab, thiab txo qhov mob.

Kev yoo mov yog ib qho nyuaj rau koj lub hlwb, thiab koj lub hlwb teb los ntawm kev hloov kho txoj kev ntxhov siab uas pab koj lub hlwb nrog kev ntxhov siab thiab kev pheej hmoo ntawm kab mob.

Cov kev hloov pauv uas tshwm sim hauv lub hlwb thaum yoo mov zoo ib yam li cov uas tshwm sim los ntawm kev tawm dag zog tsis tu ncua.

Ob hom kev hloov pauv nce cov protein ntau hauv lub hlwb (neurotrophic yam), uas nyob rau hauv lem txhawb kev loj hlob ntawm neurons, kev sib txuas ntawm lawv thiab ua rau kom muaj zog ntawm synapses.

Kev yoo mov kuj tseem txhawb kev tsim cov paj hlwb tshiab los ntawm cov qia hlwb hauv hippocampus. Tus sau kuj hais txog ketones (lub hauv paus ntawm lub zog rau cov neurons), uas yoo mov txhawb nqa, thiab qhov kev xav tias kev yoo mov tuaj yeem ua rau muaj cov mitochondria hauv cov neurons.

Raws li tus naj npawb ntawm mitochondria hauv neurons nce, lawv lub peev xwm tsim thiab tswj kev sib txuas lus nrog ib leeg kuj nce, yog li txhim kho kev kawm thiab kev nco.

"Kev yoo mov ib ntus nce lub peev xwm ntawm cov paj hlwb los kho DNA." Tus kws sau ntawv kuj tseem chwv cov evolutionary nam ntawm no txoj kev xav - yuav ua li cas peb cov poj koob yawm txwv yoog raws thiab muaj peev xwm ciaj sia tau ntev tsis muaj zaub mov.

Hauv kev tshawb fawb luam tawm nyob rau lub Rau Hli 5 qhov teeb meem ntawm Cell Stem Cell, cov kws tshawb fawb ntawm University of Southern California tau qhia tias kev yoo mov ntev ntev tiv thaiv kev puas tsuaj rau lub cev tiv thaiv kab mob thiab tseem ua rau nws rov tsim dua tshiab. Lawv xaus lus tias kev yoo mov hloov qia hlwb los ntawm lub xeev dormant mus rau lub xeev nquag.

Lub sijhawm yoo mov tua cov laus thiab puas hlwb ntawm lub cev tiv thaiv kab mob, tom qab ntawd lub cev tau tshem ntawm lawv thiab siv cov qia hlwb los tsim cov hlwb tshiab, noj qab haus huv tag nrho.

"Peb tsis tuaj yeem xav txog tias kev yoo mov ntev ntev tuaj yeem muaj txiaj ntsig zoo tshaj plaws hauv kev txhawb nqa cov qia hlwb los ntawm kev tsim kho ntawm hematopoietic system … cov hlwb, tshwj xeeb tshaj yog cov uas raug puas tsuaj. Peb pib pom tias hauv tib neeg thiab tsiaj txhu, nrog kev yoo mov ntev, cov leukocytes hauv cov ntshav txo qis. Thaum koj pib noj dua, koj cov ntshav rov qab los, "hais tias Walter Longo.

Xyoo 2007, kev tshuaj xyuas kev tshawb fawb ntawm ntau cov kev tshawb fawb ntsig txog kev yoo mov tau luam tawm hauv American Journal of Clinical Nutrition. Nws tau tshuaj xyuas ntau yam kev tshawb fawb hauv tib neeg thiab tsiaj txhu thiab txiav txim siab tias kev yoo mov yog ib txoj hauv kev zoo los txo txoj kev pheej hmoo ntawm kab mob plawv thiab mob qog noj ntshav.

Muaj peev xwm tseem ceeb kuj tau pom nyob rau hauv kev kho mob ntshav qab zib.

Ua ntej koj tshaib plab

“Ua ntej koj sim tshaib plab, xyuas kom koj npaj txhij rau nws thiab paub txaus tias dab tsi yog dab tsi.

Ib txoj hauv kev pom zoo - uas tau sim los ntawm Michael Mosley ntawm BBC los pab tshem tawm cov ntshav qab zib, cov roj cholesterol siab thiab lwm yam teeb meem ntsig txog kev rog - yog 5: 2 Kev Noj Qab Haus Huv.

Qhov kev noj haus no tau teev tseg tias nyob rau hnub yoo mov, koj txiav cov calories hauv koj cov zaub mov mus rau ib feem peb ntawm koj cov khoom noj txhua hnub (txog li 600 calories rau cov txiv neej thiab txog 500 rau cov poj niam) los ntawm kev haus dej ntau thiab tshuaj yej. Rau lwm tsib hnub, koj tuaj yeem noj tau ib txwm.

Lwm txoj hauv kev, raws li tau hais los saum no, yog txwv koj cov zaub mov kom tsawg ntawm 11 teev sawv ntxov txog 7 teev tsaus ntuj txhua hnub thiab tsis noj dab tsi ntxiv ntawm lub sijhawm.

Yog li, kev saib xyuas koj cov zaub mov, los ntawm kuv qhov kev xav, yog ib qho tseem ceeb tshaj plaws, yog tias tsis yog qhov tseem ceeb tshaj plaws, yam tseem ceeb rau kev noj qab haus huv. Qhov koj ua rau koj lub cev yog qhov tseem ceeb, thiab kuv ntseeg tias qhov kev tshawb fawb no thaum kawg yuav raug lees paub nyob rau hauv cov ntaub ntawv kho mob tsis ncaj ncees, tsis ncaj ncees, ywj pheej yav tom ntej.