Peb suav nrog kev txhaj tshuaj tiv thaiv. Ntu 5. Kev Ruaj Ntseg

2024 Tus sau: Seth Attwood | [email protected]. Kawg hloov kho: 2023-12-16 16:06

1. Qhov tseeb tias kev nyab xeeb ntawm cov tshuaj tiv thaiv yog kuaj yam tsis muaj cov placebo tiag tiag, tab sis tsuas yog sib piv nrog lwm cov tshuaj tiv thaiv, lossis piv nrog qee yam tshuaj lom, peb twb pom lawm. Tab sis tsis yog tag nrho. Muaj peb yam teeb meem nrog rau kev tshawb fawb txog kev nyab xeeb tshuaj tiv thaiv.

2. Ua ntej, yuav luag txhua qhov kev ntsuam xyuas tsuas yog ua rau cov menyuam noj qab haus huv xwb. Qhov ntawd tsis tiv thaiv cov tuam txhab tsim khoom, FDA thiab CDC los ntawm kev pom zoo txhaj tshuaj tiv thaiv rau cov menyuam yaus tsis noj qab haus huv, thiab cov menyuam mos ntxov ntxov, thiab tsis yog menyuam yaus, thiab cov menyuam yaus.

Piv txwv li, ib hlis dhau los, Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv Israeli tau pib pom zoo tshuaj tiv thaiv MMR (mob qhua pias / mumps / rubella) rau cov menyuam mos 6 lub hlis thiab laus dua uas mus rau Tebchaws Europe, txawm tias tsis muaj kev tshawb fawb txog kev nyab xeeb ntawm cov tshuaj tiv thaiv no rau cov menyuam yaus hnub nyoog qis dua ib xyoos. xyoo laus.

3. Qhov thib ob, yuav luag txhua qhov kev sim tshuaj xyuas kev nyab xeeb tsuas yog nrhiav cov teebmeem luv luv xwb. Lawv feem ntau kav ntev li ob peb hnub mus rau ob peb lub lis piam, nrog cov kev sim tsis tshua muaj ntev li ob peb lub hlis. Tag nrho cov kev mob tshwm sim tom qab lub sijhawm no, los ntawm kev txhais, tsis tuaj yeem cuam tshuam nrog cov tshuaj tiv thaiv.

4. Qhov thib peb, txawm tias thaum muaj kev phiv loj heev tshwm sim thaum lub sijhawm sim, cov kws tshawb fawb tsuas tuaj yeem txiav txim siab tias xws li lossis lwm yam kev mob tshwm sim loj, lossis kev tuag, tsis yog tshwm sim los ntawm cov tshuaj tiv thaiv, tsuas yog hla lawv tawm thiab tsis quav ntsej lawv.

5. Ntawm no yog ib qho piv txwv ntawm kev sim tshuaj rau cov tshuaj tiv thaiv Daptacel. Txhawm rau koom nrog hauv kev sim, tus menyuam yuav tsum noj qab nyob zoo, yug tom qab 37 lub lis piam, tsis nkag siab rau cov tshuaj tiv thaiv kab mob, tsis muaj kev loj hlob qeeb, tsev neeg yuav tsum tsis muaj keeb kwm ntawm kev tiv thaiv kab mob, thiab lwm yam.

Ntau lossis tsawg dua qhov yuav tsum tau muaj nyob rau hauv txhua qhov kev sim tshuaj tiv thaiv.

Qhov ntawd yog, tsis zoo li cov tshuaj uas tau sim rau cov neeg mob thiab muab rau cov neeg mob, cov tshuaj tiv thaiv tsuas yog kuaj rau cov menyuam yaus noj qab nyob zoo, thiab tom qab ntawd lawv tau muab rau cov neeg noj qab haus huv thiab tsis noj qab haus huv, thiab txawm tias mob hnyav.

6. Thiab qhov no yog tsab xov xwm uas qhia txog cov txiaj ntsig ntawm qhov kev xeem saum toj no:

Kev nyab xeeb raug kuaj 30 mus rau 60 hnub tom qab txhua koob tshuaj.

5.2% ntawm cov menyuam yaus hauv pawg xeem thiab 5.2% ntawm cov menyuam yaus hauv pawg tswj hwm (uas tau txais 3 lwm yam tshuaj tiv thaiv) tau ntsib cov teebmeem loj. Cov kws tshawb fawb tau txiav txim siab tias tag nrho cov kev mob tshwm sim loj no tsis cuam tshuam nrog kev txhaj tshuaj. Cov kws sau ntawv tsis qhia tias cov kev mob tshwm sim no yog dab tsi, thiab lawv tau xaus li cas.

Qee qhov piv txwv ntxiv:

7. Kev sim tshuaj tiv thaiv kab mob Recombivax-HB rau kab mob siab B:

Kev nyab xeeb raug kuaj rau 14 hnub.

Cov kev mob tshwm sim tau tshaj tawm hauv 77% ntawm cov menyuam yaus. Cov kev mob tshwm sim hnyav tau tshaj tawm hauv 28 tus menyuam yaus (1.6%). Ib tug me nyuam tuag (SIDS). Cov kws sau ntawv tshaj tawm tias nws txoj kev tuag yog tej zaum tsis cuam tshuam nrog cov tshuaj tiv thaiv.

8. Kev sim tshuaj tiv thaiv Comvax tiv thaiv Haemophilus influenzae thiab kab mob siab B:

Kev nyab xeeb raug kuaj rau 14 hnub.

Cov kev mob tshwm sim hnyav tau tshaj tawm hauv 17 tus menyuam mos (1.9%). 3 tug menyuam tuag (SIDS). Cov kws tshawb fawb tau xaus lus tias tag nrho cov kev mob tshwm sim loj, suav nrog kev tuag, tsis cuam tshuam rau cov tshuaj tiv thaiv.

9. Kev sim tshuaj tiv thaiv Infanrix hexa:

Kev ruaj ntseg raug kuaj rau 30 hnub.

Cov kev mob tshwm sim hnyav tau tshaj tawm hauv 79 tus menyuam mos (2.7%). Yuav luag txhua tus ntawm lawv tsis muaj dab tsi cuam tshuam nrog kev txhaj tshuaj. Ib tug me nyuam tuag (SIDS). Tau kawg, nws tsis muaj dab tsi ua nrog kev txhaj tshuaj.

10. Randomized, Controlled, Multicenter Study of the Immunogenicity and Safety of a Fully Liquid Combination Diphtheria – Tetanus Toxoid – Five-Component Acellular Pertussis (DTaP5), Inactivated Poliovirus (IPV), thiab Haemophilus influenzae Type b (Hib) Tshuaj Tiv Thaiv Cov tshuaj tiv thaiv DTaP3-IPV / Hib tau tswj hwm thaum muaj hnub nyoog 3, 5, thiab 12 lub hlis (Vesikari, 2013, Clin Vaccine Immunol.)

Kev ruaj ntseg raug kuaj rau 30 hnub.

Cov kev mob tshwm sim hnyav tau tshaj tawm hauv 8.5% ntawm cov menyuam mos. Yuav luag txhua tus ntawm lawv tsis muaj dab tsi cuam tshuam nrog kev txhaj tshuaj.

kaum ib. Immunogenicity, Safety, thiab Tolerability ntawm Hexavalent Vaccine nyob rau hauv cov me nyuam mos (Marshal, 2015, Pediatrics)

Kev nyab xeeb raug kuaj rau 6 lub hlis.

Cov kev mob tshwm sim hnyav tau tshaj tawm hauv 84 tus menyuam mos (5.9%). Ob tug tuag. Tsis muaj kev sib txuas tshuaj tiv thaiv.

12. Qhov no yog ntau lossis tsawg dua qhov kev kuaj kev nyab xeeb feem ntau zoo li. Lawv tsis tshua muaj sijhawm ntev tshaj 6 lub lis piam, lawv yuav luag ib txwm tshwm sim, lub sijhawm luv luv no, cov kev mob tshwm sim loj heev hauv cov menyuam yaus noj qab haus huv, uas yuav luag tsis cuam tshuam nrog cov tshuaj tiv thaiv.

Hauv kev sim tshuaj luv luv no, nws tsis tuaj yeem txheeb xyuas ntau yam kab mob autoimmune, mob qog noj ntshav, lossis kab mob hauv lub paj hlwb, nrog rau ntau yam kab mob uas feem ntau tshwm sim los ntawm kev txhaj tshuaj tiv thaiv (kom ua pov thawj tom qab), tab sis tsis tuaj yeem kuaj tau ntxov dua li ob peb lub hlis., lossis txawm tias ob peb xyoos tom qab txhaj tshuaj tiv thaiv.

Tsis tas li ntawd, cov tshuaj tiv thaiv kab mob feem ntau hais tias tsis muaj kev tshawb fawb tau ua los ntawm oncogenicity ntawm cov tshuaj, nrog rau nws muaj peev xwm cuam tshuam rau lub cev xeeb tub.